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These are frequently warned about due to their hypertensive effects, which are caused by their interactions with the mineralocorticoid receptors in the adrenal glands

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Numerous age-related neuroanatomical, neurophysiological, metabolic, epigenetic, and biochemical changes likely related to AD and other dementias can occur with aging, such as changes in synaptic, mitochondrial, immunological function, and gray and white matter volumes [14,15,16,17]