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Moreover, caffeine-induced STAT3 phosphorylation in the liver was inhibited in HFD-fed IL-6 −/− mice, and caffeine treatment reduced the ALT and AST levels in the HFD-fed control mice but not in the IL-6 −/− mice after 12 weeks

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These studies support the notion that early abnormalities in insulin secretion, rather than a reduction in beta cell mass, play a fundamental and primary role in early type 2 diabetes pathogenesis