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Abu-Bip-CN was identified as the most potent inhibitor in the series (half-maximal inhibitory concentration [IC 50 ], 13 ± 3 nM [pIC 50 , 8.7]) but was poorly potent in the cell assay due to rapid proteolytic withdrawal in the cell assay medium

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Thereby, particularly damaged inner plexiform and inner nuclear layer, noted at week 1, and thereby thinned retina, appear as a result of the L-NAME course