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Within the same synthetic pathways for GSH production, adequate levels of several B vitamins are essential, as they serve as enzymatic cofactors in multiple metabolic pathways contributing to GSH synthesis: (i) vitamin B6 contributes to normal cysteine synthesis, regarded as the rate-limiting factor in GSH synthesis

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They demonstrated that human pancreatic tumor and stellate cells activate/process GSAO into its active metabolite and that γGT activity positively correlates with GSAO-mediated proliferation arrest of co-cultured endothelial cells ( Figure 3B )