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Remarkably, the two top enriched GO terms within the top 100 differentially regulated genes in hematopoietic stem cells from Aldh2 −/− Adh5 −/− mice correspond to cellular response to oxygen-containing compounds (GO1901700 and GO1901701) 10 , suggesting oxidative stress might play an important role in the onset of IBMFS/AMeD phenotypes

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10.1016/j.jplph.2008.12.016 142 VaidyanathanH.SivakumarP.ChakrabartyR.ThomasG