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Human trials showed that in people with high-risk features, treatment with minocycline reduced in 6 months the risk of conversion to MS, decreased lesion volume, and showed the absence of new enhancing lesions, but this effect did not last beyond 24 months of study (Preiningerova et al., 2022)

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Oxidative stress is one of the events that possibly contributes to the development and progression of neurodegenerative disorders 48,49