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Sirtuins The Sirtuins (SIRTs) are a family of NAD + -dependent deacetylase and mono-ADP-ribosyltransferases that are likely to be found in the nucleus (Sirt6, and Sirt7), mitochondria (Sirt3-5), and nucleus and cytoplasm (Sirt1 and Sirt2), respectively [66,67,68,69]