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Blood was collected from the medial saphenous vein for the measurement of erythrocyte glutathione profiles, leucocyte GSH, plasma and erythrocyte AA profiles, mitogen-induced lymphoproliferative response, serum amyloid A (SAA), 8-hydroxy-2'-deoxyguanosine (8-OHdG), one of the major products of DNA oxidation widely used as a biomarker of oxidative stress (31) , and biochemistry and haematology parameters (Fig

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However, although A β with 42 amino acid residues (A β (1-42) ) is available in low quantities, it is highly prone to aggregation and readily self-assembles to form a heterogenous mixture of oligomers and PF subsequently deposited as fibrils in senile plaques [160, 161]