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171 Furthermore, given the chronic and recurrent nature of IBD, long-term studies are required to assess the safety and therapeutic durability of peptide-based treatments

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Preclinical research suggests that NNMT inhibition may: Influence fat-cell metabolism Reduce fat accumulation Increase energy expenditure Support healthier metabolic signalling Improve glucose handling in animal models Influence NAD+ and cellular energy pathways Potentially improve body composition without relying primarily on appetite suppression In diet-induced obese mice, NNMT inhibition has been associated with reductions in body weight and fat mass, alongside metabolic improvements