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In accordance with such a variety of functions, isoforms of this heterogeneous protein family are found in many prokaryotes as well as in the cytosol, nucleus, mitochondria, chloroplasts and/or secretory pathway of eukaryotes 1,2,3,4,5,6,7,8

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All of these conditions get worse with the progression of kidney disease and the impairment of kidney function, thus stimulating RBC death and creating a vicious circle