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Interestingly, all animals with degenerated IVDs, verified by x‐ray, T2–magnetic resonance imaging and histology, showed axial discomfort that did not persist during the 1 year follow‐up and half of these animals demonstrated signs of radiating pain that was associated with IVD narrowing and dorsal nerve innervation

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However, MDD is clinically heterogeneous, with symptoms varying between participants or within a participant over time, possibly due to differences in stress reactivity [4] or inflammation [5]