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These findings are of relevance and suggest that the baseline perturbations in airway GSH and GSSG homeostasis in subjects with asthma may increase the risk of airway injury from secondary insults such as antigen exposure

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210 Many established therapies act indirectly on these cascades: corticosteroids upregulate IκB and MAPK phosphatase-1 to inhibit NF-κB and MAPK activity, β 2 -agonists elevate cyclic AMP to suppress immune cell activation, and theophylline enhances HDAC and AMPK activity