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Treatment with the long-acting amylin analogue cagrilintide 2 induces 11.8% weight loss in humans over 68 weeks and co-administering cagrilintide with the glucagon-like peptide-1 (GLP-1) receptor agonist semaglutide produces 22.7% weight loss over 68 weeks (versus 16.1% for semaglutide alone) 3,4,5,6

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The use of mouse embryonic fibroblast (MEF) from single or double KO mice for arrestins 2 and 3 revealed that DOR desensitization induced by DPDPE relies predominantly on arrestin 3 expression suggesting a preferential interaction between DOR and this arrestin isoform (Qiu et al., 2007)