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The risk of asthma is higher in children exposed to acetaminophen during pregnancy, and that risk is exacerbated by maternal genetic variants related to acetaminophen detoxification.[ref] Genetic interactions with acetaminophen: With multiple routes of detoxification, most people can take acetaminophen without liver damage
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In neuroblastoma, the OGT/FOXC1 signaling axis drives high expression of glutamate pyruvate transaminase 2, which converts glutamate and pyruvate to alanine and α-KG