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Higher NNMT activity means more nicotinamide gets shunted away from NAD+ production

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[14] In dermal fibroblast culture and in rat wound-chamber models, GHK-Cu has been reported to modulate glycosaminoglycan and small-proteoglycan synthesis — increasing chondroitin sulphate and dermatan sulphate accumulation, raising decorin mRNA and lowering biglycan mRNA — i.e