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Both pathways are linked in some cell types by the cleavage of BID, a proapoptotic member of the Bcl-2 family of proteins, generating tBID in a process catalyzed by caspase-8 activated by the extrinsic pathways (Scaffidi et al., 1998)

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5.2.3 F3 generation effects (great-grandchildren) The F3 generation demonstrates partial recovery from EED-induced reproductive dysfunction, with sperm quality recovering by 85% (110) and hormonal profiles largely returning to baseline levels (111)