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One twin was randomly assigned to receive IGF-1 LR3 (LR3) (GroPep Bioreagents, Thebarton, ASTL) at 1.17 ± 0.12 μg·kg −1 ·h −1 (based on an average actual final fetal weight of 2.27 ± 0.41 kg), and the other twin received vehicle control (VEH) (saline with 0.5% bovine serum albumin, BSA) at 0.2 mL·h −1 to match the delivery rate of IGF-1 LR3

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People describe early changes within a week or two and a fuller effect over the cycle