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virtually everybody listening to this podcast, including Peter), the results have been surprisingly underwhelming Growth hormone can produce modest changes in body composition and increases in so-called lean body mass But lean body mass, as defined in these terms, is actually a very blunt metric A meaningful portion of that increase can actually reflect water retention and other non-contractile tissue rather than functional skeletal muscle More importantly, when you look at the outcomes people actually care about —strength, physical performance, recovery, functional capacity, and quality of life—the benefits are generally much smaller than most people imagine, and are often absent altogether That might be the strongest argument against using something like CJC-1295 We already know what happens when we push this pathway more directly Peter explains, “ If directly administering growth hormone has largely failed to produce meaningful functional benefits in growth hormone-replete adults, the burden of proof is high for claiming that an indirect growth hormone-releasing hormone will produce dramatically different results

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But because the question has not been studied directly in people, clinicians generally advise anyone with active or suspected cancer to avoid it