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For example, the reduction of SCFAs (such as butyrate) caused by gut microbiota dysbiosis weakens their inhibitory effect on HDACs, thereby enhancing the pro-inflammatory phenotype of Kupffer cells

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20 The Wnt/β-catenin pathway is essential for maintaining stem cell pluripotency and promoting osteogenic differentiation by stabilizing β-catenin, which then translocates into the nucleus to drive the expression of osteoblast-specific genes such as RUNX2 and SP7